It depends dude. Not all email accounts have 2 factor auth. Try registering some valid email accounts yourself on google, hotmail, etc and try logging under different circumstances i.e. VPNs from different countries, different browsers, etc to see what triggers the additional authentication. They might even profile each user to see their patterns of use and any anomalies to those patterns might trigger the additional auth.
If the loggins you got are from a list that has been distributed or sold to others who have also tried to log in to those accounts then forget about it. Those accounts would be on a watch list and you'll have a next to nothing chance of getting in.
I have a friend that works in IT who said they use 20 different criteria to fingerprint individuals logging into their site. Aside from browser and OS they use things like screen resolution, local PC time, language, etc.
Also, I have heard of people porting phone numbers to receive the 2FA messages but I neither condone nor recommend that.