The best way to run VortexBox in widows is in a vmware session. But it's really designed to tun an old PC into a NAS. Run widows on your desktop then turn an old PC into a VortexBox. An old PC is way more powerful than the NAS boxes they are selling now and it's a lot cheaper. You don't need to know Linux to run VortexBox it's sets everything up for you. You can connect to it from your windows machine.
As a side note VortexBox does not run on XBOX although it makes a great backend server for XBOX Media Center (XBMC). Hope this helps!