if the hardware your running will support it I would make 2 networks with a router between them.
1 with your VPN stuff
2 with your home stuff
put an ACL (access control list) on the VPN network so nothing from the VPN box can get anywhere on your home box.
Honestly though from the sound of it I would worry about the people in the rooms hopping around between your customers. I would make a separate vlan for the hotels between rooms and staff stuff. You don't the guests to be able to mess around with the front desk machines and such with credit card/home address/dates on there.
